Significantly, 13 of the 22 genes were previously known to be associated with GBM in the DisGeNET database (AQP4, BCAN, BCHE, GFAP, HOPX, MARCKSL1, NDRG2, PLEKHB1, PLP1, S100B, SLC22A17, TSPAN7, and TTYH1; hypergeometric over‐enrichment P‐value = 1.2 × 10−6; Fig 5B) (Piñero et al, 2015). This evidence concerns the gene PLEKHB1 and glioblastoma.