Gene expression changes in G0/G1 populations of KOs confirmed a reduction of Neural G0 genes and characteristic gene expression changes associated with the p53 transcriptional network, Hippo‐YAP targets, cell cycle gene regulation, and many novel targets and pathways, including those downstream of CREBBP and TAOK1. Interestingly, in glioma, Hippo‐Yap pathway activity has been shown to significantly increase with grade and is associated with shortened patient survival (Orr et al, 2011; Zhang et al, 2016a). This evidence concerns the gene CREBBP and central nervous system cancer.