SMC3 and acute myeloid leukemia: When expanding the selection to genes mutated in > 1% of the total Beat AML selection, we found mutations in ZNF711 (F: 5/222, M: 0/276, P = 0.0172) exclusively in females, while BRCC3 (F: 0/222, M: 6/276, P = 0.0358) and SMC3 (F: 1/222, M: 8/276, P = 0.047) were both significantly overrepresented in males (Fig. S3 and Table S4A).