Sex‐specific mutational profiles in AML have also been described; FLT3‐ITD, NPM1 and DNMT3A mutations are overrepresented in females [11, 12], while mutations in RUNX1, ASXL1, SRSF2, STAG2, BCOR, U2AF1 and EZH2 are more prevalent in males [12]; and female overrepresentation among AML patients with co‐occurrence of DNMT3A, NPM1 and FLT3‐ITD mutations has also been reported [13]. This evidence concerns the gene EZH2 and acute myeloid leukemia.