Comparing FLT3‐ITD‐positive (n = 98) and FLT3‐ITD‐negative specimens (n = 282) irrespective of sex, we found that GLI2, CCL1, JPH1, MDGA1, RASGRF1, AE000661.37, HOXB‐AS3, IRX5 and RP11‐713C5.1 were all significantly upregulated in FLT3‐ITD‐positive AML, while GPR126 was significantly downregulated. The gene discussed is GLI2; the disease is acute myeloid leukemia.