Several miRNAs such as miR‐21, miR‐20b and miR‐130b are dramatically up‐regulated in advanced CRC and inhibit PTEN expression, further resulting in PD‐L1 overexpression, which suggests that miRNA‐PD‐L1 axis might be a therapeutic target for CRC.11 This evidence concerns the gene CD274 and colorectal carcinoma.