COPB2 and colorectal carcinoma: Chen et al. and Wang et al. [16, 17] demonstrated that the proliferation of CRC cells results from the interaction between miR-4461/miR-216a-3p and the proto-oncogene COPB2. In addition, the effects of COPB2 and miR-335-3p were observed in lung cancer, where miR-335-3p mimics significantly increased the proliferation of lung cancer cells following COPB2 knockdown [18].