COPB2 and neoplasm: Generally, the involvement of COPB2 in tumor progression has been found to be related to the regulation of upstream genes, such as the Sensitive to apoptosis gene (SAG or RNF7) [12] and Yes-associated protein 1 (YAP1) [13]; the activation of receptor tyrosine kinase (RTK) [14] and c-jun N-terminal kinase (JNK)/c-Jun signaling pathways [15]; and the targeting of microRNAs [16–18] (Fig. 1).