COPB2 and lung adenocarcinoma: Similar to the observations on miR-4461 in CRC, miR-335-3p and miR-216a-3p have been found to target the 3′UTR of COPB2, which led to the inhibition of COPB2 in lung adenocarcinoma (LUAD) [18] and lung cancer [17] cell lines, respectively.