COPB2 and chromophobe renal cell carcinoma: Although the level of COPB2 in cancer tissues is lower than in normal tissues in adrenocortical carcinoma (ACC), kidney chromophobe (KICH), kidney renal clear cell carcinoma (KIRC), and acute myeloid leukemia (LAML), the level of COPB2 expression in most other cancer tissue types is higher than in normal tissues (Fig. 3), according to the GEPIA database.