Furthermore, the SDI and the clinical signs of SLE patients, including cutaneous manifestations, fever, oral ulcer, arthritis, neuropsychiatric lupus (NPLE), alopecia, effusion, proteinuria, leucopenia, hematuresis, pyuria, thrombocytopenia, erythrocytopenia and anemia, were analyzed and correlated with increased TIM-3+PD-1+NK cells. The gene discussed is HAVCR2; the disease is alopecia.