In addition, the MFI of PD-1 on TIM-3+PD-1+ NK cells tended to be increased in SLE patients with fever (P = 0.059), and the MFI of TIM-3 on TIM-3+PD-1+ NK cells tended to be increased in SLE patients with arthritis (P = 0.068) and thrombocytopenia (P = 0.053), although these differences were not significant. Here, HAVCR2 is linked to systemic lupus erythematosus.