These results indicated that the cell levels of TIM-3+PD-1+NK were increased, including the frequency of TIM-3+PD-1+NK cells, the MFI of TIM-3 on TIM-3+PD-1+NK cells and the MFI of PD-1 on TIM-3+PD-1+NK cells in SLE patients. Here, HAVCR2 is linked to systemic lupus erythematosus.