PDCD1 and systemic lupus erythematosus: The results indicated that the frequency of TIM-3+PD-1+ NK cells correlated positively with anti-dsDNA; the MFI of TIM-3 on TIM-3+PD-1+ NK cells was significantly increased in patients with positive anti-RIB-P, which suggested that the increased TIM-3+PD-1+ NK cells may be associated with the autoimmune response in SLE.