Furthermore, the SDI and the clinical signs of SLE patients, including cutaneous manifestations, fever, oral ulcer, arthritis, neuropsychiatric lupus (NPLE), alopecia, effusion, proteinuria, leucopenia, hematuresis, pyuria, thrombocytopenia, erythrocytopenia and anemia, were analyzed and correlated with increased TIM-3+PD-1+NK cells. The gene discussed is PDCD1; the disease is systemic lupus erythematosus.