The abnormal activation of calcineurin by stimulation with IL-1β and TNF-α in RA synoviocytes may contribute to the pathogenesis of inflammatory arthritis; however, overexpression of CABIN1, a natural calcineurin antagonist, suppressed calcineurin activity by inhibiting IL-6 and MMP-2 production by rheumatoid synoviocytes [49]. This evidence concerns the gene TNF and rheumatoid arthritis.