PRKG1 and systemic lupus erythematosus: The biological function for PRKG1 in type I IFN production or signaling was supported in dendritic cells and NK cells, which conjointly generate IFN-α in SLE [43]; however, PRKG1 function was less strongly supported in T and B lymphocytes, which are not considered to be major IFN-α producing cells [42].