Global gene expression profiling of JIA fibroblast-like synoviocytes (FLS) exhibited a hypertrophic chondrocyte phenotype and demonstrated that dysregulation of TGF-β signaling pathway along with contributions from the upregulated β-catenin signaling pathway, leading to inhibition of chondrocyte differentiation, and partially downregulated canonical Wnt signaling pathway may have implications for endochondral bone formation and contribute to bony overgrowth in oligoarticular JIA. This evidence concerns the gene TGFB1 and oligoarticular juvenile idiopathic arthritis.