The second replicated JIA locus, for which we report an association in OA-JIA sample, is VTCN1 – V-set domain-containing T cell activation inhibitor 1 – showing strongest association with JIA among non-HLA genes in previous studies [13, 14], and has been implicated as a potentially predictive disease-course marker for selected JIA subtypes [8]. This evidence concerns the gene VTCN1 and juvenile idiopathic arthritis.