Integrative omics analysis demonstrated enhanced expression of ELMO1 protein and hypomethylation of ELMO1 locus, ELMO1-promoted cell migration and invasion, and Rac1 activity regulation in RA FLSs, implicating a link between ELMO1 and RA pathogenicity and the potential of ELMO1 as a RA therapeutic target [27]. This evidence concerns the gene RAC1 and rheumatoid arthritis.