Table 2 shows the 25 most powerful predictors for SD from the univariate analysis, and 10 of them were independent predictors for SD in the multivariable model: male sex, Asian or Black race, NYHA class III/IV vs. I/II, prior CABG or PCI, history of myocardial infarction, cancer history, treatment with LCZ696 compared with enalapril, left ventricular hypertrophy (LVH) on ECG, QRS duration (90–120 ms), and plasma NT-proBNP (log-transformed). The gene discussed is NPPB; the disease is left ventricular hypertrophy.