PCNA and neoplasm: Xenografts with high nuclear localization of Survivin (SurvNESmut-GFP) exhibited similar growth rates compared to those with ‘normal’ nuclear localization (LN229) and in average grew faster to the ones with predominantly cytoplasmic Survivin (Surv-GFP), as shown by the weaker PCNA signal in the unexposed control, substantiating slower tumor cell proliferation (Fig. 6).