Table 8 summarized the frequency of haplotypes formed by STAT4 genetic polymorphisms in the case and control groups. In haplotype analysis, the covariates (age and gender) were adjusted. Logistic regression results showed that the haplotype ‘TT’ (rs11889341|rs7574865) can reduce the susceptibility of HCC among participants (crude analysis: OR = 0.81, CI = 0.66–0.99, P=0.037; adjusted by age and gender: OR = 0.81, CI = 0.66–0.99, P=0.130). This evidence concerns the gene STAT4 and hepatocellular carcinoma.