HGF/MET signaling promotes EMT and cancer invasiveness [106].• Inhibition of HGF and MET together with chemotherapy prevented metastasis in a model of PaCa [107].• HGF/MET controls EMT and metastasis via FOSL2 in NSCLC [108].• HGF-mediated cross-talk between CAFs and gastric cancer cells activates metastasis [109].• Breast cancer cells with high metastatic potential are hypersensitive to HGF secreted by macrophages [110].• MET signaling activates an inflammatory microenvironment in the brain and facilitates breast cancer metastasis to the brain [111]. The gene discussed is MET; the disease is permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome.