COL8A2 and adenoviridae infectious disease: The indel rate in corneal endothelium was 23.7 ± 4.5%, which was much lower than anticipated since COL8A2 protein expression in mouse corneal endothelium was markedly decreased by the anterior chamber injection of Ad-Cas9-Col8a2gRNA (Figure 3 and Figure 3—figure supplement 1) and because of the high rate of adenovirus infection of the corneal endothelium (Figure 2a).