Since high cholesterol is a strong risk factor for Alzheimer’s disease, whereas DHA is a protector (67, 68), it is possible that these 2 risk factors are linked due to an ACSL6 deficiency–induced DHA deficit impact upon SREBP-mediated increases in cholesterol biosynthesis genes, a finding also reported in other models of DHA deficit (30, 69, 70). This evidence concerns the gene ACSL6 and early-onset autosomal dominant Alzheimer disease.