Just two significant male VS DEGs could be attributed to an ‘environment’ effect: Erb-B2 Receptor Tyrosine Kinase 2 Interacting Protein (Erbb2ip; FC x1.9 and adj.pval = 0.004) encoding a protein associated with early-life stress, anxiety disorders and ADHD (49) and SECIS Binding Protein 2 Like (Secisbp2l; FC x1.7 and adj.pval = 0.013), linked to thyroid hormone-dependent growth and embryonic differentiation processes (50). The gene discussed is ERBIN; the disease is attention deficit-hyperactivity disorder.