Although it has been shown that REG3A, along with other Reg family members, could mediate components of RAS-RAF-MEK-ERK signaling pathway in pancreatic cancer cells48, pancreatic β cells49 and gastric cancer cells50, the detailed mechanism by which REG3A/REG3B regulates pancreatic acinar cells undergoing ADM was poorly described. The gene discussed is REG1A; the disease is familial pancreatic carcinoma.