In the current study, we demonstrated the involvement of REG3A/REG3B in the ADM process using several models including: human pancreas tissue from patients with PDAC, in vitro cultures of primary human and murine pancreatic acinar cells, an in vivo transgenic mouse model with caerulein-induced pancreatitis, and recombinant REG3B-treated wild-type mice with caerulein-induced pancreatitis. Here, REG3A is linked to pancreatitis.