Again, while stretches of conserved, noncoding DNA are most often not readily identifiable by comparison between humans/mouse and zebrafish, the presence of such dimeric SoxE sites in bona fide murine NCC enhancers33 and putative human melanoma enhancers34 is consistent with this being a general mechanism by which Sox10 target genes are upregulated in melanoma. The gene discussed is SLC12A3; the disease is melanoma.