Therefore, members of the SoxE family (most likely Sox10 or Sox9 which are expressed in the melanocyte lineage) are prime candidate transcription factors that may bind and activate peak5. The most stringent test of this prediction would require single-cell level ChIP-Seq analysis for these factors on in vivo-isolated tumor-initiating cells, a technical feat not feasible for this tissue at present. Here, SOX9 is linked to neoplasm.