SOX10 and melanoma: Dimeric SOXE binding sites are overrepresented in human melanoma cells in regions of open chromatin34 and have also been observed near promoters of genes regulated by Sox1046, suggesting that Sox10 may bind the dimeric sites in peak5. Mutation of the dimerization domain within Sox10 in mice also causes defects in melanocyte development, underscoring the importance of dimeric Sox10 binding47.