The chromatin landscape surrounding sox10 closely mirrors the previously reported ATAC-Seq profile of zebrafish NCCs (Supplementary Fig. 1B) by the 5-6 somite stage, although is not evident at earlier stages (e.g., bud or 75% epiboly) suggesting that the accessibility landscape near sox10 seen in the melanoma tumors may be most reflective of one established in late neural crest progenitors committed to a pigment cell progenitor lineage23–26. The gene discussed is SOX10; the disease is melanoma.