The deleterious effects of diabetes on SGs are related to hyperglycemia, which induces cellular abnormalities through different metabolic pathways such as non-enzymatic protein glycosylation, activation of aldose reductase and diacylglycerol phosphatidyl kinase C, and reduced hydration through the inhibition of insulin signal transduction1,3,4. This evidence concerns the gene AKR1B1 and diabetes mellitus.