In two autoinflammatory diseases, STING-associated vasculopathy with onset in infancy (SAVI)19,20 and the COPA syndrome21, STING is constitutively activated without DNA stimulation and localize not to the ER but to the perinuclear compartments that include the Golgi15,20,22–26. This evidence concerns the gene STING1 and STING-associated vasculopathy with onset in infancy.