CASP3 and posterior cortical atrophy: As our results demonstrate that MEM treatment induced apoptosis and cell cycle arrest by modulation of expression of TPD52 in both PCa cell lines (CWR22Rν1 and C4-2 cells) as shown earlier by cleavage of Caspase 3 and PARP, also by modulation of cyclin-dependent kinases in CWR22Rν1 and C4-2 cells by treatment of MEM in a dose-dependent manner (Fig. 5c).