In the current study, we determined the expression of TPD52 in N-methyl nitrosourea (MNU) treated RWPE-1 nontumorigenic cell line which generated a family of tumor cell lines in order of increasing malignancy and invasiveness which is RWPE < WPE2-NA22 < WPE1-NB14 < WPE1-NB11 < WPE1-NB26 (progression model of prostate cancer) described by the laboratory of Webber et al., (2001). This evidence concerns the gene TPD52 and prostate carcinoma.