Hyperlipidemia in LDL receptor-deficient (ldlr−/−) or Lipoprotein E-deficient mice also activates other innate immunity signaling pathways that depend on their mainstays, namely Toll-like Receptors, TLR-2, TLR-3, and TLR-4, along with their intracellular adaptors, MyD88, TRAM, and TRIF16–18. Here, TLR2 is linked to hyperlipidemia.