Shown in Fig. 2A, significant increase in the levels of IL-1β, IL-18 and caspase 1 were detected in the soup of PBMCs isolated from patients with CAPS at 1 h and 4 h upon LPS stimuli in comparison to those isolated from sJIA and healthy controls (all p < 0.05). Here, IL18 is linked to cryopyrin-associated periodic syndrome.