NLRP3 and cryopyrin-associated periodic syndrome: In fact, the diagnosis of CAPS usually requires genetic evidence of NLRP3/cold-induced autoinflammatory syndrome 1 (CIAS1) germline gene mutations8, while mutations in NOD-like receptor family pyrin domain containing 12 (NLRP12) and somatic mosaicism of NLRP3 were also reported9,10.