Additionally, patients with sJIA have higher levels of inflammatory cytokines in all parameters tested when compared to healthy controls (38.6 ± 58.68 vs. 1.5 ± 0.7, 13.0 ± 11.7 vs. 0.8 ± 1.2, 1244.0 ± 612.8 vs. 568.8 ± 171.9, 10.8 ± 5.8 vs. 4.4 ± 1.6 and 11.6 ± 7.2 vs. 1.1 ± 0.6 for IL-1β, IL-6, IL-18, TNF-α and SAA; p = 0.04, 0.002, 0.002, 0.001 and 0.001 respectively). Here, IL1B is linked to systemic-onset juvenile idiopathic arthritis.