Based on the bulk RNA-seq data from GEM tumors, we found that DNA methyltransferases (Dnmt1, Dnmt3b), demethylase (Tet1), and methyl-CpG binding domain genes (Mbd3 and Mbd4) were differentially upregulated, while Mbd2 and Zbtb4 were downregulated in poorly differentiated foci compared to adenocarcinoma foci (Fig. 7a). This evidence concerns the gene DNMT1 and adenocarcinoma.