Furthermore, based on the N-Myc ChIP-seq data, we found that N-Myc binding was enhanced at the promoters of Dnmt1, Dnmt3b, and Mdb4 in PRN (primarily poorly differentiated histology) compared to PN tumors (primarily adenocarcinoma histology, Fig. 7b). The gene discussed is MYCN; the disease is adenocarcinoma.