Based on the bulk RNA-seq data from GEM tumors, we found that DNA methyltransferases (Dnmt1, Dnmt3b), demethylase (Tet1), and methyl-CpG binding domain genes (Mbd3 and Mbd4) were differentially upregulated, while Mbd2 and Zbtb4 were downregulated in poorly differentiated foci compared to adenocarcinoma foci (Fig. 7a). The gene discussed is MBD3; the disease is adenocarcinoma.