Some of these foci, however, were positive for the neuroendocrine marker INSM118,19, EZH2, as well as NKX2-1, a marker associated with small cell neuroendocrine carcinomas (including prostate)18–20 (Fig. 1c, d and Supplementary Fig. 1d, e). Here, NKX2-1 is linked to small cell carcinoma.