Furthermore, based on the N-Myc ChIP-seq data, we found that N-Myc binding was enhanced at the promoters of Dnmt1, Dnmt3b, and Mdb4 in PRN (primarily poorly differentiated histology) compared to PN tumors (primarily adenocarcinoma histology, Fig. 7b). Here, DNMT3B is linked to peripheral nervous system neoplasm.