TMPRSS2 and neoplasm: Interestingly, Esr1, Fgfr3, and AR target genes, Fkbp5 and Tmprss2, were differentially hypermethylated and downregulated while regulators of cell differentiation and neural development (e.g., Slit2, Prox1, and Olig1) were hypomethylated and upregulated in poorly differentiated tumor foci compared to adenocarcinoma foci (Fig. 7d).