We also isolated bone marrow neutrophils from the KPC mouse model (KrasLSL-G12D/+;Trp53LSL-R172H/+;Pdx1–Cre) with pancreatic tumors and demonstrated that FES was among the group of kinases with significant increased activity compared to neutrophils from tumor-free control mice (Supplementary Fig. 1b). Here, FES is linked to pancreatic neoplasm.