Lorlatinib (PF-06463922) is an FDA-approved, third-generation, ATP-competitive small-molecule tyrosine kinase inhibitor that shows promising results in pre-clinical tests and clinical trials in patients suffering from non-small-cell lung cancer with genetic rearrangements of anaplastic lymphoma kinase (ALK) or ROS124,25. The gene discussed is ALK; the disease is non-small cell lung carcinoma.