CD8A and neoplasm: Finally, while we did not see an improved tumor response to the combination of lorlatinib and gemcitabine compared with lorlatinib alone, we demonstrate that lorlatinib can improve the therapeutic response to anti-PD-1 treatment leading to reduced tumor size compared with lorlatinib or anti-PD-1 treatments alone and increased accumulation and activation of CD8+ T cells, which would be important for PDAC patients.