FES and neoplasm: We determined that Fes is expressed in CD11b + -sorted myeloid cells from an orthotopic PDAC tumor (Supplementary Fig. 1c) and we further confirmed that Fes is expressed at the highest level in neutrophils by analyzing Fes expression in neutrophils (Ly6G+), monocytes (Ly6C+) and macrophages (F4/80+) sorted from pancreatic tumors from the KPC mouse model (Supplementary Fig. 1d).