GPX4 and neoplasm: Additionally, H&E staining indicates no distinct pathological changes in major organs (hearts, livers, spleens, lungs, and kidneys) of tumor-bearing mice after different treatments for 14 days (Supplementary Fig. 36), while the GPX4 expressions in major organs of mice in all experimental groups show normal expression levels (Supplementary Fig. 37), demonstrating the excellent compatibility and negligible side effect of FHPG.