Using FISH, 4 separate assays (BCL2,-BA (break-apart), BCL6-BA, MYC-BA, MYC-IGH-F(fusion)) are needed to diagnose DH/TH lymphomas, while still missing those cases that carry a MYC-IGL translocation since no commercial probes are available for MYC-IGL fusion FISH. The gene discussed is MYC; the disease is lymphoma.