We also generated a MLH1 minigene spanning exons 16–18 harboring the c.1989G > A mutation (Supplementary Data 2) which leads to skipping of exon 17 and causes hereditary nonpolyposis colorectal cancer (HNPCC) or Lynch syndrome (MIM# 120435)14,67. This evidence concerns the gene MLH1 and hereditary nonpolyposis colon cancer.