IRAG2 and parasitic infectious disease: Collectively, these data demonstrate that Lrmp, a p53 target gene, is important for tuft cells to respond to the infections of protozoa and helminth parasites and trigger intestinal type 2 immunity, and suggest that Lrmp is an important mediator for the role of p53 in regulating type 2 immunity in response to parasitic infections (Fig. 6f).