Indeed, providing succinate in drinking water induced the intestinal type 2 immune response in p53+/+ mice; succinate induced hyperplasia of tuft and goblet cells, induced eosinophilia, increased ILC2 numbers, and increased the levels of IL-13 and IL-4 in p53+/+ mice (Fig. 2a–c, Fig. S2). The gene discussed is TP53; the disease is Increased total eosinophil count.