Administering rIL-25 (i.p., 0.5 μg/day for 7 days) to mice induced hyperplasia of tuft and goblet cells, increased the population of eosinophils and ILC2s, and increased the levels of IL-13 and IL-4 to a similar extent in p53+/+ and p53−/− mice (Fig. 2e–g, Fig. S3b–d), suggesting that p53 loss impairs the function of tuft cells in response to parasitic infections, which can be restored by administration of rIL-25. This evidence concerns the gene IL4 and parasitic infectious disease.