Given the strong downregulation of E2F1 expression observed upon Salmonella infection (30% of control at 20 hpi), and considering that only about 25–30% of the cells are infected in the experimental conditions analyzed, we hypothesized that E2F1 downregulation could occur not only in infected cells but also in the bystander cell population. This evidence concerns the gene E2F1 and Salmonella Infections.