Overall, these results demonstrate that also in an animal model, Salmonella infection results in a strong downregulation of E2F1 expression, likely triggered by activation of the IRE1 branch of the ER-stress response pathway, as well as the consequent downregulation of E2F1-dependent miRNAs further supporting their relevance for the infection process. The gene discussed is ERN1; the disease is Salmonella Infections.