Combining each independent risk factor, we found that risk of these irAE was 6.85 (95% CI 3.49–13.44) times higher in female anti-PD-L1 treated patients with above-median hypothyroidism PRS and above-median baseline TSH levels as compared to male anti-PD-L1 treated patients with below-median PRS and below-median baseline TSH levels (Fig. 3c). The gene discussed is CD274; the disease is hypothyroidism.