INS and Hypoglycemia: The increase in insulin sensitivity observed in Sam68LKO mice was corroborated via hyperinsulinemic-euglycemic clamp assessments: when mice were systemically infused with insulin, the amount of glucose required to compensate for the increase in insulin levels and prevent hypoglycemia was significantly greater for Sam68LKO mice than for their Sam68f/f littermates (Fig. 1k).