To confirm that the diabetic phenotypes of HFD-fed and db/db mice could be at least partially attributed to the observed increase in Sam68 expression, experiments were conducted in Sam68LKO and Sam68fl/fl that had been fed via the HFD protocol to induce diabetes, and in db/db mice after injection with AAV8 coding for Sam68 shRNA (db/db; sh-Sam68 mice) or a scrambled sequence (db/db; sh-Scr); the Sam68 shRNA reduced Sam68 mRNA and protein levels in the liver by 77% and 70%, respectively, but not in other organs (Fig. 6d, e, Supplementary Fig. 6d). The gene discussed is KHDRBS1; the disease is diabetes mellitus.