Proteomics analyses of blood samples from ICU patients with COVID-19 uncovered protein trajectories that mirror the recently reported immune trajectory in COVID-19 and add further granularity to COVID-19 biology, in particular with regard to complement activators of the innate immune system (MBL2/PTX3) being associated with mortality; and recovery of several liver-derived proteins being linked to survival86. The gene discussed is PTX3; the disease is COVID-19.