We observed DZ GC B cells (CXCR4+ CD86−), TZ, (CXCR4+ CD86−), and LZ (CXCR4− CD86+) in HPV+ HNSCC and normal and inflamed tonsils (Fig. 5f, Supplementary Fig. 8a, b). The gene discussed is CXCR4; the disease is head and neck squamous cell carcinoma.