PLCG2 and Alzheimer disease: Our analysis also strengthened the evidence of association with AD for three additional genomic loci including an association with a variant in PLCG2 (rs3935877, MAF = 0.13, OR = 0.92 [0.90–0.95], p = 6.9 × 10−9, Fig. 2d), and confirmed another common variant in PLCG2, a stop gain mutation in IL-34 and a variant near HS3ST1 (Table 1, Supplementary Fig. 3 and Supplementary Data 2, 3).