The level of TRPM2 also increased as the patients’ TNM stage increased (Fig. 2b), meanwhile, the patients’ overall survival (OS) period significantly shortened as the TNM stage (Pearson’s coefficient = −0.92) and TRPM2 level (Pearson’s coefficient = −0.88) increased in pancreatic cancer patients (Fig. 2c). Here, TRPM2 is linked to familial pancreatic carcinoma.