BRCA1 and neoplasm: ++Oxtr tumors showed significantly increased expression of Tgfα (P < 0.0001), Egfr (P = 0.008), Akt1 (P < 0.0001), and Brca1 (P < 0.0001) (Fig. 3H), and decreased expression of tumor suppressor and apoptosis genes Tgfβ1 (P < 0.0001), Pten (P < 0.0001), p53 (P < 0.0001), and Bcl2 (P < 0.0001) (Fig. 3I).