In PCa, 137 genes were differentially expressed between tumor and normal tissues (Supplementary Fig. S1B), which HJURP was most significantly upregulated in PCa (fold change = 6.2, P < 0.05, Supplementary Fig. S1C), and its mRNA levels were substantially elevated among the eight tumors (Fig. 2A). The gene discussed is HJURP; the disease is posterior cortical atrophy.