Kato et al.6 revealed that, in cancer cells, HJURP promotes homologous recombination and rDNA stability through interaction with human mutS homolog 5 (hMSH5) and MRE11-RAD50-NBS1 protein complex, which contributes to immortality and genomic stability in osteosarcoma, lung, and testicular cancer. Here, MSH5 is linked to osteosarcoma.