Remarkably, increased DGCR5 expression in ESCC tissues was significantly related to a deeper invasion range (P = 0.0252), more lymph node metastasis (P = 0.0008) and higher TNM stage (P = 0.0008), while not related with age and gender (Table 1). The gene discussed is DGCR5; the disease is esophageal squamous cell carcinoma.