NSD1 and Sotos syndrome: Nuclear receptor binding SET domain-containing protein 1 (NSD1), encoded by the Nsd1 gene, catalyzes the mono- and dimethylation of histone H3 at lysine 36 (H3K36).13 In the clinic, deletion or mutation of the NSD1 gene are the major causes of Sotos syndrome (cerebral gigantism),14,15 a genetic disorder with increased bone growth during infancy and childhood and normal height after puberty,16 strongly indicating that NSD1 is associated with bone growth.