Nuclear receptor binding SET domain-containing protein 1 (NSD1), encoded by the Nsd1 gene, catalyzes the mono- and dimethylation of histone H3 at lysine 36 (H3K36).13 In the clinic, deletion or mutation of the NSD1 gene are the major causes of Sotos syndrome (cerebral gigantism),14,15 a genetic disorder with increased bone growth during infancy and childhood and normal height after puberty,16 strongly indicating that NSD1 is associated with bone growth. This evidence concerns the gene NSD1 and hereditary disease.