FLT3 and acute myeloid leukemia: Based on the roles the ERK pathway plays in the regulation of Bcl-2 family proteins and the role the STAT5 pathway plays in regulating Mcl-1 in the context of FLT3-ITD31–34, we assessed alterations in the Bcl-2 family of proteins in the FLT3-ITD AML cell lines and a primary patient sample, upon exposure to CUDC-907, gilteritinib, both, or vehicle control.