S100A8 and S100A9, mainly expressed in myeloid cells, including neutrophils, monocytes, and macrophages, and some other cell types with secretory functions, including tissue epithelial cells, endothelial cells, and keratinocytes, have been involved in multiple chronic inflammatory diseases, such as cancer, thrombosis and arthritis [5–9]. This evidence concerns the gene S100A9 and cancer.