SIRT1 and allergic asthma: To further elucidate the role of SIRT1 in allergic airway inflammation in vivo, we established allergic asthma model using Sirt1fl/fl littermates and Sirt1fl/fl-LysMCre mice, as described in Figure 1A Compared with asthmatic Sirt1fl/fl mice, SIRT1 expression in lung tissue was significantly decreased in asthmatic Sirt1fl/fl-LysMCre mice (Figure 4A).