Dysregulated YY1 has been reported to lead to dysregulated cellular metabolism including glycometabolism, lipid metabolism, and bile acid metabolism in the liver, which is believed to be one of the underlying mechanisms of how YY1 is involved in various liver diseases (Lu et al, 2013; Verdeguer et al, 2014; Zhang et al, 2017). Here, YY1 is linked to liver disorder.