Interestingly, the authors observed that individuals with deletions encompassing the 3’ end of AUTS2, encoding the C-terminal isoform of AUTS2 and expressed in the brain, tended to manifest more syndromic features such as microcephaly and facial dysmorphism, which were further recapitulated in zebrafish models for the C-terminal isoform [4]. Here, AUTS2 is linked to microcephaly.