The MEblue module correlated with the Os, and the genes were significantly upregulated and enriched with GO processes associated with host cell invasion and environmental adaptation, such as G cell adhesion and motility, ER to Golgi vesicle-mediated transport, receptor-mediated virion attachment to host cell, and cell surface receptor signaling pathway, and KEGG pathways such as quorum sensing, HIF-1 signaling, and longevity-related pathways (Fig. 8d), once again supporting its role as the main infection source for the host animal. Here, CD177 is linked to infection.