A recent study has shown TECs isolated from hypoxic highly metastatic tumours contained more aneuploid cells, had enhanced proliferative and invasive capacity and had enhanced mRNA expression of pro-angiogenic (VEGF, VEGFR1/2, HIF-1α) and stemness genes than TECs derived from low metastatic tumours [65]. This evidence concerns the gene FLT1 and neoplasm.