In RCC, hypoxia-induced HIF-1α promoted EMT in RCC cell lines through increased expression of ZEB1 and ZEB2 and E2A immunoglobulin enhancer-binding factors E12/E47 (TCF3), which suppressed E-cadherin expression, leading to the attainment of a mesenchymal phenotype in these cells [55]. The gene discussed is ZEB1; the disease is renal cell carcinoma.