In another study on the PBMC of 40 RCC patients identified CD8+PD-1+TIM-3+Lag3+ TILs, CD4+ICOS+TILs and CD25+CD127+Foxp3/Helios+ GITR+Tregs phenotype to be associated with high risk of disease progression after nephrectomy within the same year [94]. This evidence concerns the gene LAG3 and renal cell carcinoma.