We then cultured the ccRCC cell line 769P under normoxic and hypoxic conditions and assessed the expressions of the 24 genes, which were CA4, WFDC2, GPD1, CCDC64, ANK3, WDR72, SMIM24, LHFPL, FLRT3, HMGCS2, UGT3A1, TMEM125, ABP1, SMTNL2, TRNP1, SLC6A19, EMX2, LRRC19, GATM, AQP1, TFA, KCNJ15, SLC16A12 and MFAP4. The gene discussed is CA4; the disease is nonpapillary renal cell carcinoma.