We then cultured the ccRCC cell line 769P under normoxic and hypoxic conditions and assessed the expressions of the 24 genes, which were CA4, WFDC2, GPD1, CCDC64, ANK3, WDR72, SMIM24, LHFPL, FLRT3, HMGCS2, UGT3A1, TMEM125, ABP1, SMTNL2, TRNP1, SLC6A19, EMX2, LRRC19, GATM, AQP1, TFA, KCNJ15, SLC16A12 and MFAP4. This evidence concerns the gene AQP1 and nonpapillary renal cell carcinoma.