We then cultured the ccRCC cell line 769P under normoxic and hypoxic conditions and assessed the expressions of the 24 genes, which were CA4, WFDC2, GPD1, CCDC64, ANK3, WDR72, SMIM24, LHFPL, FLRT3, HMGCS2, UGT3A1, TMEM125, ABP1, SMTNL2, TRNP1, SLC6A19, EMX2, LRRC19, GATM, AQP1, TFA, KCNJ15, SLC16A12 and MFAP4. Here, HMGCS2 is linked to nonpapillary renal cell carcinoma.