To examine the possibility that GPD1 and GPD2 expressions were regulated by HIF transcription factors, we treated the ccRCC cell line RCC4 with a PHD inhibitor, dimethyloxalylglycine (DMOG), and a proteasome inhibitor, MG132, both of which stabilize HIFs. The gene discussed is GPD1; the disease is nonpapillary renal cell carcinoma.