IDH3A and central nervous system cancer: To improve the diagnostic accuracy of glioma and predict the prognosis of glioma patients more accurately, The World Health Organization (WHO) in 2016 defined the subclassification of glioma using molecular parameters including the co-deletion of chromosomal 1p and 19q(chr1p/19q), and the mutational status of isocitrate dehydrogenase (IDH) [1].