In contrast, according to the triggering role of an ACE2/Ang II imbalance in SARS-CoV-2 pathogenicity [20, 21], we hypothesized that COVID-19 might be attenuated by direct maintenance of innate pulmonary redox, dilation and metabolic functions using a combination of well-tolerated medications via aerosol delivery to human airways. Here, ACE2 is linked to COVID-19.