As Table 3 and figure showed, with the optimal cut-off value of 87.21, the SOX14 methylation positive rate was 3.70% (1/27) in the normal group, 58.33% (21/36) in the CINII group, 81.81% (27/33) in the CINIII group, and 94.12% (16/17) in the cancer group. The gene discussed is SOX14; the disease is cancer.