As previously reported, quercetin and crocetin were able to inhibit MAPK- or PI3K/AKT-mediated BCL-2 expression; promote the expression of caspase-3, caspase-8, caspase-9, and PARP so that tumor cells-cycle was inhibited, and apoptosis of tumor cell initiated [19]. Here, CASP8 is linked to neoplasm.