To gain mechanistic insight into histone deacetylation and acetylation-/methylation-associated TF regulation, we examined the transcript levels of key TF genes involved in liver development (Hnf4a and Hnf6), liver fibrosis (Aebp1 and 2, Smad2, and Hmgb2), steatosis and lipogenesis (Pparγ, Sox4, Fxr, Chrebp, Pparα, Irf6, and Srebf1), oxidative stress (Klf4 and Atf4), and apoptosis (Irf6). The gene discussed is SMAD2; the disease is Hepatic fibrosis.