Our previous studies on DNA methylation in liver from WD patients showed hypermethylated WD liver DMRs were enriched in liver-specific enhancers, flanking active liver promoters and binding sites of liver developmental transcription factors, including HNF4A, RXRA, and FOXA2,9 which were recapitulated in the top 10 transcription factors enriched in this RNA-seq data set. This evidence concerns the gene HNF4A and Wilson disease.